Our capabilities in space are growing almost as fast as our ambitions. Many nations, companies, and private actors are currently vying to secure historic “firsts” in space, raising complex social and ethical questions. There is surprisingly little serious analysis of these issues, however, and they are rarely discussed in undergraduate class discussions, despite their popularity with students. To help correct this deficit, a student research team designed 11 case studies to help instructors across the curriculum introduce space into their classes. (...) These are designed for ease of use, with self-contained background information, suggested readings/movies, and a series of juicy questions. (shrink)

Recent estimates indicate that over 40,000 children die annually in the United States and a majority have life-limiting conditions. Children at end of life require extensive healthcare resources, including multiple hospital readmissions and emergency room visits. Yet, many children still suffer from symptoms at end of life—including fatigue, pain, dyspnea, and anxiety—with less than 10% of these children utilizing hospice care services. A critical barrier to pediatric hospice use was the original federal regulations associated with the hospice care that required (...) a diagnosis of 6 months to live and the discontinuation of all curative treatments. The Concurrent Care Provision of the United States’ Affordable Care Act eliminated the need to forgo curative therapies in order to enroll in hospice for children in Medicaid or Children’s Health Insurance Program. Concurrent care for children can help mitigate the tension families experience in choosing between essential forms of care, as well as contribute to improved end-of-life outcomes for the child and possibly bereavement outcomes for the family. Understanding concurrent care for children from a social justice perspective has important advocacy and research implications for hospice and palliative care clinicians providing care for children and their families. We apply Powers and Faden’s theory of social justice “as the moral foundation of public health and health policy” to the provision of concurrent care to children near end of life and families in the United States. The goals of applying this theory are to explore additional insights and perspectives into concurrent care policy may provide and to assess the usefulness of this theory when applied to end-of-life health policy. We argue that concurrent care policy is socially just since it has potential to promote well-being in vulnerable children and families and can limit the inequity children at end-of-life experience in access to high-quality hospice care. (shrink)

A report of a problem-based learning project on the ethics of terminal care, offered as one of the options available to first year MB ChB students in Edinburgh University Medical School. The project formed part of the 'clinical correlation course' in the new curriculum. Six students took part under the supervision of two clinical tutors and a moral philosopher. The course was case-based and practical with students being given the opportunity over a period of eight weeks to meet patients, relatives (...) and hospital staff at a local geriatrics hospital and terminal care home. The main issue studied was the degree of choice available to patients electing to be treated at home, in hospital or in a hospice. Other issues included: pre-death, disposal of the dead, certification of death, communication with relatives and follow-up bereavement services. (shrink)

Annotation Scholars of medieval scholastic philosophy as well as those who study semiotics will appreciate this side-by-side translation, with introduction, by Doyle (Saint Louis U.) of a late 16th-early 17th century Jesuit text. The text (its name is taken from the U. of Coimbra, in Portugal, where the authors taught) contains commentaries on Aristotle, as part of a course in philosophy, particularly logic. Annotation c. Book News, Inc., Portland, OR (booknews.com).

Background The scrutiny surrounding gender-affirming medical treatment (GAMT) for youth has increased, particularly concerning the limited evidence on long-term treatment outcomes. The Standards of Care 8 by the World Professional Association for Transgender Health addresses this by outlining research evidence suggesting “effective” outcomes of GAMT for adolescents. However, claims concerning what are considered “effective” outcomes of GAMT for adolescents remain implicit, requiring further reflection. Methods Using trans negativity as a theoretical lens, we conducted a theory-informed reflexive thematic analysis of the (...) literature cited in the “Research Evidence” section of the SOC8 Adolescents chapter. We selected 16 articles that used quantitative measures to assess GAMT outcomes for youth, examining how “effective” outcomes were framed and interpreted to uncover implicit and explicit normative assumptions within the evidence base. Results A total of 44 different measures were used to assess GAMT outcomes for youth, covering physical, psychological, and psychosocial constructs. We identified four main themes regarding the normative assumptions of “effective” treatment outcomes: (1) doing bad: experiencing distress before GAMT, (2) moving toward a static gender identity and binary presentation, (3) doing better: overall improvement after GAMT, and (4) the absence of regret. These themes reveal implicit norms about what GAMT for youth should achieve, with improvement being the benchmark for “effectiveness.” Discussion We critically reflect on these themes through the lens of trans negativity to challenge what constitutes “effective” GAMT outcomes for youth. We explore how improvement justifies GAMT for youth and address the limitations of this notion. Conclusions We emphasize the need for an explicit discussion on the objectives of GAMT for adolescents. The linear narrative of improvement in GAMT for adolescents is limited and fails to capture the complexity of GAMT experiences. With currently no consensus on how the “effectiveness” of GAMT for adolescents is assessed, this article calls for participatory action research that centers the voices of young TGD individuals. (shrink)

Dicer is a key player in microRNA (miRNA) and RNA interference (RNAi) pathways, processing miRNA precursors and doublestranded RNA into ~21-nt-long products ultimately triggering sequence-dependent gene silencing. Although processing of substrates in vertebrate cells occurs in the cytoplasm, there is growing evidence suggesting Dicer is also present and functional in the nucleus. To address this possibility, we searched for a nuclear localization signal (NLS) in human Dicer and identified its C-terminal double-stranded RNA binding domain (dsRBD) as harboring NLS activity. We (...) show that the dsRBD-NLS can mediate nuclear import of a reporter protein via interaction with importins β, 7, and 8. In the context of full-length Dicer, the dsRBD-NLS is masked. However, duplication of the dsRBD localizes the full-length protein to the nucleus. Furthermore, deletion of the N-terminal helicase domain results in partial accumulation of Dicer in the nucleus upon leptomycin B treatment, indicating that CRM1 contributes to nuclear export of Dicer. Finally, we demonstrate that human Dicer has the ability to shuttle between the nucleus and the cytoplasm. We conclude that Dicer is a shuttling protein whose steady-state localization is cytoplasmic. (shrink)

A close reading of Psalm 58, focusing particularly on its stylistic features, reveals the centrality of God's presence to his people in the midst of injustice and evil. In spite of its imprecatory language, Psalm 58 is a song of God's saving activity and a celebration of justice. A powerful seven-fold curse full of rich yet horrific images calls out for the disempowerment of the wicked. The Hebrew text, together with significant text-critical notes, along with a critical translation, colometric division (...) and examination of stylistic features constitutes the first part of the article. The structuring and non-structuring elements of the poem lead us to its primary theological purpose which is discussed in the second half of the article. Placing Psalm 58 within the context of the lament genre, the purpose of its difficult words is examined. In line with authors such as W. Brueggemann and C. Stuhlmueller an attempt is made to surface the significance of formal language of violence in the search for theological meaning. A hermeneutic for understanding and utilising the imprecatory psalms as a form of speech which gives voice to our disorientation and the disorientation of others is presented. In conclusion, the article points out how the often hyperbolic and ugly language of Psalm 58 reflects a biblical spirituality which should not be denied in the prayer forms of the community. (shrink)

_An entertaining and provocative investigation of friendship in all its variety, from ancient times to the present day_ A central bond, a cherished value, a unique relationship, a profound human need, a type of love. What is the nature of friendship, and what is its significance in our lives? How has friendship changed since the ancient Greeks began to analyze it, and how has modern technology altered its very definition? In this fascinating exploration of friendship through the ages, one of (...) the most thought-provoking philosophers of our time tracks historical ideas of friendship, gathers a diversity of friendship stories from the annals of myth and literature, and provides unexpected insights into our friends, ourselves, and the role of friendships in an ethical life. A. C. Grayling roves the rich traditions of friendship in literature, culture, art, and philosophy, bringing into his discussion familiar pairs as well as unfamiliar—Achilles and Patroclus, David and Jonathan, Coleridge and Wordsworth, Huck Finn and Jim. Grayling lays out major philosophical interpretations of friendship, then offers his own take, drawing on personal experiences and an acute awareness of vast cultural shifts that have occurred. With penetrating insight he addresses internet-based friendship, contemporary mixed gender friendships, how friendships may supersede family relationships, one’s duty within friendship, the idea of friendship to humanity, and many other topics of universal interest. (shrink)

In his major new book A.C. Grayling examines the different ways to live a good life, as proposed from classical antiquity to the recent present. Grayling focuses on the two very different conceptions of what a good life should be: one is a broadly secular view rooted in attitudes about human nature and the human condition; the other is a broadly transcendental view which locates the source of moral value outside the human realm. In the modern world - the world (...) shaped by the rise of science in the seventeenth century - these two views have come increasingly into conflict, and the constantly accumulating tension between them is one of the greatest problems faced by the twenty-first century. Using his renowned clarity of thought and philosophical rigour, AC Grayling has produced an invaluable guide through mankind's ethical struggle to live decently. (shrink)

With his clear and accessible prose, impeccable scholarship, and balanced Judgment, Roland Teske, SJ, has been an influential and important voice in Medieval philosophy for more than thirty years. This volume, in his honour, brings together more than a dozen essays on central metaphysical and theological themes in Augustine and other medieval thinkers. The authors, listed below, are noted scholars who draw upon Teskes work, reflect on it, go beyond it, and at times even disagree with it, but always in (...) a spirit of respectful co-operation, and always with the aim of getting at the truth. Essays on Augustine contributed by Gerald Bonner, Charles Brittain, Joseph Koterski, SJ, Joseph T. Lienhard, SJ, David Vincent Meconi, SJ, Ann A. Pang-White, Frederick Van Fleteren, Dorothea Weber, and James Wetzel. Essays on Bernard of Clairvaux, William of Auvergne, and other medieval themes contributed by John P. Doyle, William Harmless, SJ, John A. Laumakis, Edward P. Mahoney, and Philipp W. Rosemann. (shrink)

Born in Bolton on 13 July 1938, the son of a mill-worker, Martin William Doyle was educated at St Joseph's R.C. primary school and then, having obtained an academic scholarship, at Thornleigh Salesian College. He entered the Order of Friars Minor at the age of 16, made his solemn profession the day after his twenty-first birthday and was ordained to the priesthood on 16 July 1961, which required a dispensation in view of his young age. This was followed by (...) studies in Rome at the Athenaeum Antonianum, 1962-64, where Doyle trained as an ecclesiastical historian and where he received his doctorate summa cum laude, obtaining maximum possible marks.Inspired by Vatican Council II Doyle was at the forefront of the renewal... (shrink)

With his clear and accessible prose, impeccable scholarship, and balanced Judgment, Roland Teske, SJ, has been an influential and important voice in Medieval philosophy for more than thirty years. This volume, in his honour, brings together more than a dozen essays on central metaphysical and theological themes in Augustine and other medieval thinkers. The authors, listed below, are noted scholars who draw upon Teskes work, reflect on it, go beyond it, and at times even disagree with it, but always in (...) a spirit of respectful co-operation, and always with the aim of getting at the truth. Essays on Augustine contributed by Gerald Bonner, Charles Brittain, Joseph Koterski, SJ, Joseph T. Lienhard, SJ, David Vincent Meconi, SJ, Ann A. Pang-White, Frederick Van Fleteren, Dorothea Weber, and James Wetzel. Essays on Bernard of Clairvaux, William of Auvergne, and other medieval themes contributed by John P. Doyle, William Harmless, SJ, John A. Laumakis, Edward P. Mahoney, and Philipp W. Rosemann. (shrink)

I do not think that the existence of God can be proved or even that the main justification for the belief can be found in argument in the ordinary sense of that term, but I think two of the three which have, since Kant at least, been classified as the traditional arguments of natural theology have some force and are worthy of serious consideration. This consideration I shall now proceed to give. I cannot say this of the remaining one of (...) the arguments, the ‘ontological proof’, which I shall therefore not discuss here. (shrink)

In this benchmark five-volume study, originally published between 1922 and 1955, Surendranath Dasgupta examines the principal schools of thought that define Indian philosophy. A unifying force greater than art, literature, religion, or science, Professor Dasgupta describes philosophy as the most important achievement of Indian thought, arguing that an understanding of its history is necessary to appreciate the significance and potentialities of India's complex culture. Volume I offers an examination of the Vedas and the Brahmanas, the earlier Upanisads, and the six (...) systems of Indian philosophy. (shrink)

This six volume backlist collection brings together an assortment of seminal works by highly influential British philosopher A. C. Ewing. This comprehensive and diverse collection encompasses a fantastic selection of his work in the field of moral philosophy and the history of philosophy; ranging from the definition of good, through to his views on punishment and a study on the work of Emmanuel Kant. Spanning more than 30 years in Professor Ewing’s distinguished career, the reissued volumes in this collection, originally (...) published between 1924 and 1959, offer a thorough and engaging insight into Professor Ewing’s work. (shrink)

A careful and competent introduction to the Russell-Broad type of analytic philosophy.--A. C. P.

Messages describing life after death from the author's deceased brother-in-law.--A. C. P.

The point of formalisation is to model various aspects of natural language. Perhaps the main use to which formalisation is put is to model and explain inferential relations between different sentences. Judged solely by this objective, a formalisation is successful in modelling the inferential network of natural language sentences to the extent that it mirrors this network. There is surprisingly little literature on the criteria of good formalisation, and even less on the question of what it is for a formalisation (...) to mirror the inferential network of a natural language or some fragment of it. This paper takes some exploratory steps towards a quantitative account of the main ingredient in the goodness of a formalisation. We introduce and critically examine a mathematical model of how well a formalisation mirrors natural-language inferential relations. (shrink)

In her groundbreaking book, Epistemic Injustice, renowned moral philosopher and social epistemologist Miranda Fricker coined the term epistemic injustice to draw attention to the pervasive impact of epistemic oppression on marginalized social groups. Fricker’s account spurred a flurry of scholarship regarding the discriminatory impact of epistemic injustice and gave birth to a domain of philosophical inquiry that has extended far beyond the disciplinary boundaries of philosophy. In this interview, Fricker responds to questions posed by A. C. Nikolaidis and Winston C. (...) Thompson that address the ways in which epistemic injustice intersects with education as a human endeavour and social institution. In doing so, Fricker reflects on her motivations in writing her book more than fifteen years ago and explicitly addresses some of the most significant contributions of the concept of epistemic injustice as a tool for analysing issues in education. She also offers insights on the purpose of education, outlines educational manifestations of epistemic injustice, and discusses the virtues that educators must exhibit and inculcate in their students in order for epistemic justice to obtain. (shrink)

AC Grayling is Britain’s leading popular philosopher. A professor at Birkbeck College, University of London, he has written over 20 books, ranging from academic monographs such as Truth, Meaning and Realism to more accessible works such as What is Good? and The Mystery of Things. His most recent books are Towards The Light and The Choice of Hercules.

'Updating Bertrand Russell for the 21st century... a cerebrally enjoyable survey, written with great clarity and touches of wit... The non-western section throws up some fascinating revelations' Sunday Times The story of philosophy is an epic tale: an exploration of the ideas, views and teachings of some of the most creative minds known to humanity. But since the long-popular classic Bertrand Russell's History of Western Philosophy, first published in 1945, there has been no comprehensive and entertaining, single-volume history of this (...) great intellectual journey. With his characteristic clarity and elegance A. C. Grayling takes the reader from the world-views and moralities before the age of the Buddha, Confucius and Socrates, through Christianity's dominance of the European mind to the Renaissance and Enlightenment, and on to Mill, Nietzsche, Sartre, and philosophy today. And, since the story of philosophy is incomplete without mention of the great philosophical traditions of India, China and the Persian-Arabic world, he gives a comparative survey of them too. Intelligible for students and eye-opening for philosophy readers, he covers epistemology, metaphysics, ethics, aesthetics, logic, the philosophy of mind, the philosophy of language, political philosophy and the history of debates in these areas of enquiry, through the ideas of the celebrated philosophers as well as less well-known influential thinkers. He also asks what we have learnt from this body of thought, and what progress is still to be made. The first authoritative and accessible single-volume history of philosophy for decades, remarkable for its range and clarity, this is a landmark work. (shrink)

Although the role of morphology in evolutionary theory remains a subject of debate, assessing the contributions of morphological investigation to evolutionary developmental biology (Evo-devo) is a more circumscribed issue of direct relevance to ongoing research. Historical studies of morphologically oriented researchers and the formation of the Modern Synthesis in the Anglo-American context identify a recurring theme: the synthetic theory of evolution did not capture multiple levels of biological organization. When this feature is incorporated into a philosophical framework for explaining the (...) origin of evolutionary innovations and novelties (a core domain of inquiry in Evo-devo) two specific roles for morphology can be described: (1) the conceptualization and operational identification of the targets of explanation; and (2) the elucidation of causal interactions at higher levels of organization during ontogeny and through evolutionary time. These roles are critical components of any adequate explanation of innovation and novelty though not exhaustive of the parts played by morphology in evolutionary investigation. They also invite reflection on what counts as an evolutionary cause in contemporary evolutionary biology. (shrink)

Scholars of epistemology have identified two conceptions of epistemic injustice: discriminatory epistemic injustice and distributive epistemic injustice. The former refers to wrongs to one’s capacity as a knower that are the result of identity prejudice. The latter refers to violations of one’s right to know what one is entitled to know. This essay advances a third conception, formative epistemic injustice, which refers to wrongs to one’s capacity as a knower that are the result of or result in malformation—the undue restriction (...) of one’s formative capacities. The author argues that formative epistemic injustice is a distinctly educational wrong and that it brings to light important epistemic injustices that standard accounts of epistemic injustice either downplay or are unable to capture. This third conception of epistemic injustice is an important analytic tool for theorizing both epistemic injustice and educational justice. (shrink)

This chapter describes the theoretical implications of Extended Synthesis and addresses the methodological options available for determining aspects of theoretical structure. It uses a “bottom-up” approach focused on evolutionary theory in particular, as opposed to a “top-down” strategy that attempts to characterize the structure of all scientific theories. The chapter shows that there are multiple stable components contained within a broad representation of evolutionary theory. It suggests that the philosophical analysis offered in the chapter regarding the structure of evolutionary theory (...) assists attempts to recover coherence through the vehicle of an Extended Synthesis. (shrink)

This paper focuses on abstraction as a mode of reasoning that facilitates a productive relationship between philosophy and science. Using examples from evolutionary developmental biology, I argue that there are two areas where abstraction can be relevant to science: reasoning explication and problem clarification. The value of abstraction is characterized in terms of methodology (modeling or data gathering) and epistemology (explanatory evaluation or data interpretation).

Logical monism is the claim that there is a single correct logic, the 'one true logic' of our title. The view has evident appeal, as it reflects assumptions made in ordinary reasoning as well as in mathematics, the sciences, and the law. In all these spheres, we tend to believe that there aredeterminate facts about the validity of arguments. Despite its evident appeal, however, logical monism must meet two challenges. The first is the challenge from logical pluralism, according to which (...) there is more than one correct logic. The second challenge is to determine which form of logicalmonism is the correct one. One True Logic is the first monograph to explicitly articulate a version of logical monism and defend it against the first challenge. It provides a critical overview of the monism vs pluralism debate and argues for the former. It also responds to the second challenge by defending a particularmonism, based on a highly infinitary logic. It breaks new ground on a number of fronts and unifies disparate discussions in the philosophical and logical literature. In particular, it generalises the Tarski-Sher criterion of logicality, provides a novel defence of this generalisation, offers a clearnew argument for the logicality of infinitary logic and replies to recent pluralist arguments. (shrink)

This volume surveys the new global landscape for democratic civic education. Rooted in qualitative researc, the contributors explore the many ways that notions of democracy and citizenship have been implemented in recent education policy, curriculum, and classroom practice around the world. From Indonesia to the Spokane Reservation and El Salvador to Estonia, these chapters reveal a striking diversity of approaches to political socialization in varying cultural and institutional contexts. By bringing to bear the methodological, conceptual and theoretical perspectives of qualitative (...) research, this book adds important new voices to one of educationOs most critical debates: how to form democratic citizens in a changing world. (shrink)

A traditional approach to teaching medical ethics aims to provide knowledge about ethics. This is in line with an epistemological view on ethics in which moral expertise is assumed to be located in theoretical knowledge and not in the moral experience of healthcare professionals. The aim of this paper is to present an alternative, contextual approach to teaching ethics, which is grounded in a pragmatic-hermeneutical and dialogical ethics. This approach is called moral case deliberation. Within moral case deliberation, healthcare professionals (...) bring in their actual moral questions during a structured dialogue. The ethicist facilitates the learning process by using various conversation methods in order to find answers to the case and to develop moral competencies. The case deliberations are not unique events, but are a structural part of the professional training on the work floor within healthcare institutions. This article presents the underlying theory on ethics and illustrates this approach with an example of a moral case deliberation project in a Dutch psychiatric hospital. The project was evaluated using the method of responsive evaluation. This method provided us with rich information about the implementation process and effects the research process itself also lent support to the process of implementation. (shrink)

In this series of studies A. C. Grayling looks at approaches the problem of how sceptical challenges can be met.

Our best scientific theories explain a wide range of empirical phenomena, make accurate predictions, and are widely believed. Since many of these theories make ample use of mathematics, it is natural to see them as confirming its truth. Perhaps the use of mathematics in science even gives us reason to believe in the existence of abstract mathematical objects such as numbers and sets. These issues lie at the heart of the Indispensability Argument, to which this Element is devoted. The Element's (...) first half traces the evolution of the Indispensability Argument from its origins in Quine and Putnam's works, taking in naturalism, confirmational holism, Field's program, and the use of idealisations in science along the way. Its second half examines the explanatory version of the Indispensability Argument, and focuses on several more recent versions of easy-road and hard-road fictionalism respectively. (shrink)